May 12, 2017
Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
| Re: | G1 Therapeutics, Inc. |
Registration Statement on Form S-1 (File No. 333-217285)
Ladies and Gentlemen:
Pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Securities Act”), we, the representatives of the underwriters (the “Representatives”), hereby join in the request of G1 Therapeutics, Inc., a Delaware corporation (the “Registrant”), for the acceleration of the effective date of the Registrant’s Registration Statement on Form S-1 (File No. 333-217285) (the “Registration Statement”), relating to a public offering of shares of the Registrant’s common stock, par value $0.0001 per share, so that the Registration Statement may be declared effective at 3:00 PM Eastern time, on May 16, 2017, or as soon thereafter as practicable. We, the undersigned Representatives, confirm that the underwriters are aware of their obligations under the Securities Act.
Additionally, pursuant to Rule 460 of the Securities Act, we hereby advise you that we have distributed approximately 2,493 copies of the Preliminary Prospectus dated May 8, 2017 through the date hereof, to underwriters, dealers, institutional investors and others.
We, the undersigned Representatives, hereby represent on behalf of the underwriters that the underwriters are acting in compliance and will act in compliance with the provisions of Rule 15c2-8 promulgated under the Securities Exchange Act of 1934, as amended, in connection with the above proposed offering.
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| Very truly yours,
J.P. Morgan Securities LLC Cowen and Company, LLC
Acting severally on behalf of themselves and the several underwriters
J.P. MORGAN SECURITIES LLC | ||
| By: | /s/ David Ke | |
| Name: David Ke Title: Vice President | ||
| COWEN AND COMPANY, LLC | ||
| By: | /s/ Jason Fenton | |
| Name: Jason Fenton Title: Managing Director | ||
[Underwriters’ Acceleration Request Signature Page]