Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No.    )



Filed by the Registrant   ☒                         Filed by a Party other than the Registrant   ☐

Check the appropriate box:


Preliminary Proxy Statement


Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))


Definitive Proxy Statement


Definitive Additional Materials


Soliciting Material Under §240.14a-12

G1 Therapeutics, Inc.

(Name of Registrant as Specified in Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check all boxes that apply):


No fee required.


Fee paid previously with preliminary materials.


Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.



OnlineGo to or scan the QR code login details are located in the shaded bar below.Votes submitted electronically must be received by June 14, 2023 at 11:59 P.M., local time.Stockholder Meeting NoticeImportant Notice Regarding the Availability of Proxy Materials for the G1 Therapeutics, Inc. Stockholder Meeting to be Held on June 15, 2023Under Securities and Exchange Commission rules, you are receiving this notice that the proxy materials for the annual stockholders meeting are available on the Internet. Follow the instructions below to view the materials and vote online or request a copy. The items to be voted on and location of the annual meeting are on the reverse side. Your vote is important! This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. The Form 10-K, Notice and Proxy Statement for the year ended December 31, 2022, are available Online Access View your proxy materials and vote.Step 1: Go to Step 2: Click on Cast Your Vote or Request Materials. Step 3: Follow the instructions on the screen to log in.Step 4: Make your selections as instructed on each screen for your delivery preferences. Step 5: Vote your shares.When you go online, you can also help the environment by consenting to receive electronic delivery of future materials.Obtaining a Copy of the Proxy Materials If you want to receive a copy of the proxy materials, you must request one. There is no charge to you for requesting a copy. Please make your request as instructed on the reverse side on or before June 1, 2023 to facilitate timely delivery.


Stockholder Meeting NoticeG1 Therapeutics, Inc.s Annual Meeting of Stockholders will be held on June 15, 2023 at G1 Therapeutics, Inc., 700 Park Offices Drive, Research Triangle Park, NC 27709, at 7:30 a.m. local time. Proposals to be voted on at the meeting are listed below along with the Board of Directors recommendations.The Board of Directors recommends a vote FOR the election of the nominees listed, FOR Proposals 2 and 3: 1. The election of three Class III directors. Nominees: Garry A. Nicholson Mark A. Velleca, M.D., Ph.D. Glenn P. Muir 2. An advisory (non-binding) vote to approve executive compensation 3. The ratification of the appointment of PricewaterhouseCoopers LLP as G1 Therapeutics, Inc.s independent registered public accounting firm for the fiscal year ending December 31, 2023PLEASE NOTE YOU CANNOT VOTE BY RETURNING THIS NOTICE. To vote your shares you must go online or request a paper copy of the proxy materials to receive a proxy card. If you wish to attend and vote at the meeting, please bring this notice with you.Heres how to order a copy of the proxy materials and select delivery preferences: Current and future delivery requests can be submitted using the options below. If you request an email copy, you will receive an email with a link to the current meeting materials.PLEASE NOTE: You must use the number in the shaded bar on the reverse side when requesting a copy of the proxy materials. Internet Go to Click Cast Your Vote or Request Materials. Phone Call us free of charge at 1-866-641-4276. Email Send an email to with Proxy Materials G1 Therapeutics, Inc. in the subject line. Include your full name and address, plus the number located in the shaded bar on the reverse side, and state that you want a paper copy of the meeting materials. To facilitate timely delivery, all requests for a paper copy of proxy materials must be received by June 1, 2023.