G1 Therapeutics Announces Publication in Cancer Discovery Demonstrating That CDK4/6 Inhibition Enhances the Anti-Tumor T Cell Response
The research, conducted in collaboration with leading academic cancer centers, demonstrates that transient inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) with trilaciclib (and other selective CDK4/6 inhibitors) activates effector T cells and enhances anti-tumor immunity in preclinical models. While chronic exposure to CDK4/6 inhibitors can block T cell proliferation, in vivo studies showed that short-term exposure to CDK4/6 inhibitors results in increased T cell recruitment and enhanced effector cell function in tumors, which significantly augments anti-tumor efficacy of checkpoint inhibitors.
“This research reinforces our hypothesis that transient inhibition of CDK4/6 is critical for enhancing anti-tumor immunity,” said
“We believe that the addition of trilaciclib to chemotherapy/checkpoint combinations will not only preserve immune system function, but will also directly enhance effector T cell activity,” added Raj Malik, MD, Chief Medical Officer of G1. “Trilaciclib, the only short-acting, intravenous CDK4/6 inhibitor in development, is currently being tested in four Phase 2 trials, including a study in small-cell lung cancer patients receiving chemotherapy and Tecentriq®, with or without trilaciclib (ClinicalTrials.gov Identifier: NCT03041311).”
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This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "will," "expect," "plan," "anticipate," "estimate," "intend," and similar expressions (as well as other words or expressions referencing future events, conditions, or circumstances) are intended to identify forward-looking statements. Forward-looking statements in this news release include, but are not limited to, the therapeutic potential of trilaciclib, G1T38 and G1T48, and are based on G1 Therapeutics’ expectations and assumptions as of the date of this press release. Each of these forward-looking statements involves risks and uncertainties. Factors that may cause G1 Therapeutics’ actual results to differ from those expressed or implied in the forward-looking statements in this press release are discussed in G1 Therapeutics’ filings with the
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